Choline Fenofibrate ( ABT-335 | ABT 335 | ABT335 )

产品货号. M16211 CAS No. 856676-23-8

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

Choline Fenofibrate
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

一种用于治疗高脂血症的 PPARα 激动剂。
产品描述

A PPARα agonist used for treatment of hyperlipidemia; increases SHP gene expression in cultured liver cells and in the normal and diabetic mouse liver by activating AMPK signaling pathway.Hypercholesterolemia Approved(In Vivo):Choline Fenofibrate exhibits excellent absolute oral bioavailability (rat 93.4%) and Cmax (rat 7944.2 ng/mL) following oral administration (rat 4mg/kg).Choline Fenofibrate exhibits terminal elimination half-life (rat 5.4 h) following intravenous injection (rat 4mg/kg).
体外实验

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体内实验

Choline Fenofibrate exhibits excellent absolute oral bioavailability (rat 93.4%) and Cmax (rat 7944.2 ng/mL) following oral administration (rat 4mg/kg).Choline Fenofibrate exhibits terminal elimination half-life (rat 5.4 h) following intravenous injection (rat 4mg/kg). Animal Model:Male Sprague-Dawley (SD) rats (200-250g)Dosage:4 mg/kg (Pharmacokinetic Analysis)Administration:Intravenous injection and oral administrationResult:Oral bioavailability (93.4%), Cmax (7944.2 ng/mL), T1/2 (5.4 h).
同义词

ABT-335 | ABT 335 | ABT335
通路

Metabolic Enzyme/Protease
靶点

PPAR
受体

Others
研究领域

Cardiovascular Disease
适应症

Hypercholesterolemia

CAS Number

856676-23-8
分子量

421.9144
分子式

C22H28ClNO5
纯度

>98% (HPLC)
溶解度

DMSO: 6.2 mg/mL (Need ultrasonic and warming)
SMILES

OCC[N+](C)(C)C.CC(C)(OC1=CC=CC=C1C(C2=CC=C(Cl)C=C2)=O)C([O-])=O
化学全称

Ethanaminium, 2-hydroxy-N,N,N-trimethyl-, 2-[4-(4-chlorobenzoyl)phenoxy]-2-methylpropanoate (1:1)

1. Chanda D, et al. Hepatology. 2009 Sep;50(3):880-92. 2. Lever M, et al. J Clin Lipidol. 2014 Jul-Aug;8(4):433-40.

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